Does the food processing contaminant acrylamide cause developmental neurotoxicity? A review and identification of knowledge gaps

There is a worldwide concern on adverse health effects of dietary exposure to acrylamide (AA) due its presence in commonly consumed foods. AA formed when carbohydrate rich foods containing asparagine and reducing sugars are prepared at high temperatures low moisture conditions. Upon oral intake, rapidly absorbed distributed all organs. known human neurotoxicant that can reach the developing foetus via placental transfer breast milk. Although neurodevelopmental have been observed after prenatal rodents, brain has so far not studied humans. However, epidemiological studies indicate gestational impair foetal growth associated with reduced head circumference neonate. Thus, there an urgent need for further research elucidate whether pre- perinatal humans might neurodevelopment adversely affect neuronal function postnatally. Here, we review literature emphasis identification critical knowledge gaps relation toxicity mode action suggest strategies close these better protect unborn child.